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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-11-2
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pubmed:abstractText |
The status of estrogen receptor-? (ER?) is critical to the clinical prognosis and therapeutic approach in breast cancer. ER?-negative breast cancer is clinically aggressive and has a poor prognosis because of the lack of hormone target-directed therapies. Previous studies have shown that epigenetic regulation plays a major role in ER? silencing in human breast cancer cells. Dietary green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), is believed to be an anticancer agent in part through its regulation of epigenetic processes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1476-4598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
274
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pubmed:meshHeading |
pubmed-meshheading:20946668-Antineoplastic Agents,
pubmed-meshheading:20946668-Blotting, Western,
pubmed-meshheading:20946668-Breast Neoplasms,
pubmed-meshheading:20946668-Catechin,
pubmed-meshheading:20946668-Cell Line, Tumor,
pubmed-meshheading:20946668-Cell Survival,
pubmed-meshheading:20946668-Chromatin Immunoprecipitation,
pubmed-meshheading:20946668-DNA Methylation,
pubmed-meshheading:20946668-Drug Synergism,
pubmed-meshheading:20946668-Estrogen Receptor alpha,
pubmed-meshheading:20946668-Female,
pubmed-meshheading:20946668-Histone Deacetylase Inhibitors,
pubmed-meshheading:20946668-Humans,
pubmed-meshheading:20946668-Hydroxamic Acids,
pubmed-meshheading:20946668-Polymerase Chain Reaction,
pubmed-meshheading:20946668-Promoter Regions, Genetic,
pubmed-meshheading:20946668-Tamoxifen
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pubmed:year |
2010
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pubmed:articleTitle |
Synergistic epigenetic reactivation of estrogen receptor-? (ER?) by combined green tea polyphenol and histone deacetylase inhibitor in ER?-negative breast cancer cells.
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pubmed:affiliation |
Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard Birmingham, AL 35294, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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