Source:http://linkedlifedata.com/resource/pubmed/id/20946642
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2010-11-5
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pubmed:abstractText |
Comprehensively understanding corticosteroid pharmacogenomic effects is an essential step towards an insight into the underlying molecular mechanisms for both beneficial and detrimental clinical effects. Nevertheless, even in a single tissue different methods of corticosteroid administration can induce different patterns of expression and regulatory control structures. Therefore, rich in vivo datasets of pharmacological time-series with two dosing regimens sampled from rat liver are examined for temporal patterns of changes in gene expression and their regulatory commonalities.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1471-2105
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
515
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pubmed:meshHeading |
pubmed-meshheading:20946642-Animals,
pubmed-meshheading:20946642-Gene Expression Profiling,
pubmed-meshheading:20946642-Gene Expression Regulation,
pubmed-meshheading:20946642-Glucocorticoids,
pubmed-meshheading:20946642-Liver,
pubmed-meshheading:20946642-Pharmacogenetics,
pubmed-meshheading:20946642-Rats,
pubmed-meshheading:20946642-Transcription, Genetic,
pubmed-meshheading:20946642-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: transcriptional dynamics and regulatory structures.
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pubmed:affiliation |
BioMaPS Institute for Quantitative Biology, Rutgers University, Piscataway, New Jersey, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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