Source:http://linkedlifedata.com/resource/pubmed/id/20946524
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-10-15
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| pubmed:abstractText |
Non-immune injury leading to interstitial fibrosis and tubular atrophy (IF/TA) in renal allografts has various etiologies, but pathological means of verification have yet to be developed. Medullary ray injury (MRI) is a pathological feature of many non-immune injuries inducing IF/TA and pathological determination of calcineurin inhibitor (CNI) toxicity proceeding to striped fibrosis. We investigated the contribution of CNI toxicity to MRI and other non-immune etiologies related to IF/TA. In this study MRI is defined as fibrosis and inflammation localized exclusively to the medullary ray. Thirty-six protocol biopsies showing MRI were analyzed and classified histopathologically as following: MRI related to CNI toxicity; chronic obstruction or reflux nephropathy; and acute or chronic pyelonephritis. The etiology of MRI was CNI toxicity (n= 16, 44.4%), chronic obstruction (n= 13, 36.1%), acute or chronic pyelonephritis (n= 2, 5.6%), and other (n= 5, 13.9%). We performed cystography in seven cases of MRI related to chronic obstruction or reflux nephropathy and six cases showing vesicoureteral reflux. The ci+ct score showed significant progression after one year in 30 of the 36 cases (1.53 ± 1.04 vs. 3.03 ± 1.13, P < 0.01). MRI has various etiologies and may also predict changes in urological complications. The classification of MRI may be useful to determine the non-immune etiology leading to IF/TA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1440-1827
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| pubmed:author |
pubmed-author:AkiokaYukoY,
pubmed-author:HattoriMotoshiM,
pubmed-author:HosoyaTatsuoT,
pubmed-author:ItoShinichiS,
pubmed-author:KobayashiAkimitsuA,
pubmed-author:TanabeKazunariK,
pubmed-author:TeraokaSatoshiS,
pubmed-author:YamaguchiYutakaY,
pubmed-author:YamamotoHiroyasuH,
pubmed-author:YamamotoIzumiI
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| pubmed:copyrightInfo |
© 2010 The Authors. Pathology International © 2010 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
60
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
744-9
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| pubmed:meshHeading |
pubmed-meshheading:20946524-Adult,
pubmed-meshheading:20946524-Female,
pubmed-meshheading:20946524-Fibrosis,
pubmed-meshheading:20946524-Humans,
pubmed-meshheading:20946524-Inflammation,
pubmed-meshheading:20946524-Kidney,
pubmed-meshheading:20946524-Kidney Transplantation,
pubmed-meshheading:20946524-Male,
pubmed-meshheading:20946524-Statistics, Nonparametric
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| pubmed:year |
2010
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| pubmed:articleTitle |
Medullary ray injury in renal allografts.
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| pubmed:affiliation |
Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan. akimitsu@kk.iij4u.or.jp
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| pubmed:publicationType |
Journal Article
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