Source:http://linkedlifedata.com/resource/pubmed/id/20946355
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-2-22
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| pubmed:abstractText |
Twin studies suggest that genetic factors play a substantial role in anorexia nervosa (AN) and self-induced vomiting (SV), a key symptom that is shared among different types of eating disorders (EDs). We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV. The first allele frequencies of all the SNPs were compared between a Dutch case group (182 AN, 149 EDs characterized by SV) and 607 controls. Associations rendering P-values < 0.05 from this initial study were then tested for replication in a meta-analysis with two additional independent ED case-control samples, together providing 887 AN cases, 306 cases with an ED characterized by SV and 1914 controls. A significant effect for the minor C-allele of tryptophan hydroxylase 2 rs1473473 was observed for both AN [odds ratio (OR) = 1.30, 95% CI 1.08-1.57, P < 0.003] and EDs characterized by SV (OR = 1.52, 95% CI 1.28-2.04, P < 0.006). In the combined case group, a dominant effect was observed for rs1473473 (OR = 1.38, 95% CI 1.16-1.64, P < 0.0003). The meta-analysis revealed that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1601-183X
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| pubmed:author |
pubmed-author:AdanR A HRA,
pubmed-author:BartelsMM,
pubmed-author:BoomsmaD IDI,
pubmed-author:BrandysM KMK,
pubmed-author:EhrlichSS,
pubmed-author:FleischhakerCC,
pubmed-author:HebebrandJJ,
pubmed-author:Herpertz-DahlmannBB,
pubmed-author:HerpertzSS,
pubmed-author:HerzogWW,
pubmed-author:HinneyAA,
pubmed-author:Houwing-DuistermaatJ JJJ,
pubmed-author:KlampflKK,
pubmed-author:MeulenbeltII,
pubmed-author:MiddeldorpC MCM,
pubmed-author:OnkenhoutE JEJ,
pubmed-author:SandersNN,
pubmed-author:ScheragSS,
pubmed-author:SlagboomP EPE,
pubmed-author:Slof-Op 't LandtM C TMC,
pubmed-author:SuchimanEE,
pubmed-author:VinkJ MJM,
pubmed-author:ZeeckAA,
pubmed-author:ZipfelSS,
pubmed-author:de ZwaanMM,
pubmed-author:van BeijsterveldtC E MCE,
pubmed-author:van ElburgA AAA,
pubmed-author:van FurthE FEF,
pubmed-author:van TrierJJ
|
| pubmed:copyrightInfo |
© 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
10
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
236-43
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| pubmed:meshHeading |
pubmed-meshheading:20946355-Adolescent,
pubmed-meshheading:20946355-Adult,
pubmed-meshheading:20946355-Alleles,
pubmed-meshheading:20946355-Anorexia Nervosa,
pubmed-meshheading:20946355-Body Weight,
pubmed-meshheading:20946355-Bulimia Nervosa,
pubmed-meshheading:20946355-Case-Control Studies,
pubmed-meshheading:20946355-DNA,
pubmed-meshheading:20946355-Data Interpretation, Statistical,
pubmed-meshheading:20946355-Eating Disorders,
pubmed-meshheading:20946355-Female,
pubmed-meshheading:20946355-Genetic Predisposition to Disease,
pubmed-meshheading:20946355-Genome-Wide Association Study,
pubmed-meshheading:20946355-Genotype,
pubmed-meshheading:20946355-Humans,
pubmed-meshheading:20946355-Male,
pubmed-meshheading:20946355-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20946355-Polymorphism, Single Nucleotide,
pubmed-meshheading:20946355-Tryptophan Hydroxylase,
pubmed-meshheading:20946355-Young Adult
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting.
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| pubmed:affiliation |
Center for Eating Disorders Ursula, Leidschendam, The Netherlands. r.optlandt@centrumeetstoornissen.nl
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
|