Linked Life Data

20945851

Source:http://linkedlifedata.com/resource/pubmed/id/20945851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2010-11-12
pubmed:abstractText
A scalable synthesis of a potent renin inhibitor (1) is described. The absolute stereochemistry is set via an unprecedented diastereoselective Dieckmann cyclization directed by a remote chiral protecting group. This transformation enables preparation of chiral 1,3-[3.3.1]-diazabicyclononenes by desymmetrization of alkyl-esters, with selectivities ranging from 4 to 17:1.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1523-7052
pubmed:author
pubmed:issnType
Electronic
pubmed:day
19
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5146-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Practical synthesis of a renin inhibitor via a diastereoselective Dieckmann cyclization.
pubmed:affiliation
Merck Frosst, Centre for Therapeutic Research, Department of Process Research, 16711 TransCanada Highway, Kirkland, Que?bec, Canada, H9H 3L1. danny_gauVreau@merck.com
pubmed:publicationType
Journal Article