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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-10-14
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pubmed:abstractText |
A wide variety of xenobiotic carboxylic acids are metabolized to their amino acid conjugates via a pathway that exists primarily in liver and kidney. This conjugation occurs in a two-step pathway catalyzed by two distinct types of enzymes, ligases and transferases. Measurements of acyl-CoA ligase activity include monitoring the rate of appearance of AMP or PPi, or the CoA adduct. N-acyltransferases catalyze formation of an amino acid conjugate from the CoA-activated intermediate, releasing CoA. This reaction is monitored by following the release of free CoA or the disappearance of the acyl-CoA adduct.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1934-9262
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
Chapter 4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
Unit4.11
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pubmed:meshHeading |
pubmed-meshheading:20945302-Acyl Coenzyme A,
pubmed-meshheading:20945302-Amino Acids,
pubmed-meshheading:20945302-Amino-Acid N-Acetyltransferase,
pubmed-meshheading:20945302-Animals,
pubmed-meshheading:20945302-Biotransformation,
pubmed-meshheading:20945302-Carboxylic Acids,
pubmed-meshheading:20945302-Coenzyme A Ligases,
pubmed-meshheading:20945302-Humans,
pubmed-meshheading:20945302-Metabolic Detoxication, Phase II,
pubmed-meshheading:20945302-Toxicology
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pubmed:year |
2003
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pubmed:articleTitle |
Techniques for measuring the activity of carboxylic acid:CoA ligase and acyl-CoA:amino acid N-acyltransferase: the amino acid conjugation pathway.
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pubmed:affiliation |
Veterans Administration Medical Center, San Francisco, California, USA.
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pubmed:publicationType |
Journal Article
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