Linked Life Data

20944663

Source:http://linkedlifedata.com/resource/pubmed/id/20944663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-10-20
pubmed:abstractText
Recent studies have deepened our understanding of multiple mechanisms by which extracellular matrix (ECM) molecules regulate various aspects of synaptic plasticity and have strengthened a link between the ECM and learning and memory. New findings also support the view that the ECM is important for homeostatic processes, such as scaling of synaptic responses, metaplasticity and stabilization of synaptic connectivity. Activity-dependent modification of the ECM affects the formation of dendritic filopodia and the growth of dendritic spines. Thus, the ECM has a dual role as a promoter of structural and functional plasticity and as a degradable stabilizer of neural microcircuits. Both of these aspects are likely to be important for mental health.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1471-0048
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
735-46
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The dual role of the extracellular matrix in synaptic plasticity and homeostasis.
pubmed:affiliation
Department of Neuroscience and Brain Technologies, Italian Institute of Technology, via Morego 30, Genoa, Italy. alexander.dityatev@iit.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't