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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 10
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pubmed:dateCreated |
2010-10-14
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pubmed:databankReference |
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pubmed:abstractText |
The crystal structure of PA1994 from Pseudomonas aeruginosa, a member of the Pfam PF06475 family classified as a domain of unknown function (DUF1089), reveals a novel fold comprising a 15-stranded ?-sheet wrapped around a single ?-helix that assembles into a tight dimeric arrangement. The remote structural similarity to lipoprotein localization factors, in addition to the presence of an acidic pocket that is conserved in DUF1089 homologs, phospholipid-binding and sugar-binding proteins, indicate a role for PA1994 and the DUF1089 family in glycolipid metabolism. Genome-context analysis lends further support to the involvement of this family of proteins in glycolipid metabolism and indicates possible activation of DUF1089 homologs under conditions of bacterial cell-wall stress or host-pathogen interactions.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1744-3091
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pubmed:author |
pubmed-author:AbdubekPolatP,
pubmed-author:AstakhovaTamaraT,
pubmed-author:BakolitsaConstantinaC,
pubmed-author:CarltonDennisD,
pubmed-author:ChiuHsiu JuHJ,
pubmed-author:DeaconAshley MAM,
pubmed-author:DellerMarc CMC,
pubmed-author:DuanLianL,
pubmed-author:EliasYlvaY,
pubmed-author:ElsligerMarc AndréMA,
pubmed-author:FeuerhelmJulieJ,
pubmed-author:GodzikAdamA,
pubmed-author:GrantJoanna CJC,
pubmed-author:GrzechnikSlawomir KSK,
pubmed-author:HanGye WonGW,
pubmed-author:HodgsonKeith OKO,
pubmed-author:JaroszewskiLukaszL,
pubmed-author:JinKevin KKK,
pubmed-author:KlockHeath EHE,
pubmed-author:KnuthMark WMW,
pubmed-author:KozbialPiotrP,
pubmed-author:KrishnaS SriSS,
pubmed-author:KumarAbhinavA,
pubmed-author:LesleyScott ASA,
pubmed-author:MarcianoDavidD,
pubmed-author:McMullanDanielD,
pubmed-author:MillerMitchell DMD,
pubmed-author:MorseAndrew TAT,
pubmed-author:NajmanovichRafaelR,
pubmed-author:NigoghossianEdwardE,
pubmed-author:OkachLindaL,
pubmed-author:OommachenSilvyaS,
pubmed-author:PaulsenJessicaJ,
pubmed-author:ReyesRonR,
pubmed-author:RifeChristopher LCL,
pubmed-author:ThomasClaytonC,
pubmed-author:TroutChristina VCV,
pubmed-author:WeekesDanaD,
pubmed-author:WhiteAprilfawnA,
pubmed-author:WilsonIan AIA,
pubmed-author:WooleyJohnJ,
pubmed-author:XuQingpingQ,
pubmed-author:van den BedemHenryH
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1211-7
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pubmed:meshHeading |
pubmed-meshheading:20944213-Amino Acid Sequence,
pubmed-meshheading:20944213-Bacterial Proteins,
pubmed-meshheading:20944213-Crystallography, X-Ray,
pubmed-meshheading:20944213-Genome, Bacterial,
pubmed-meshheading:20944213-Glycolipids,
pubmed-meshheading:20944213-Models, Molecular,
pubmed-meshheading:20944213-Molecular Sequence Data,
pubmed-meshheading:20944213-Protein Folding,
pubmed-meshheading:20944213-Protein Structure, Quaternary,
pubmed-meshheading:20944213-Protein Structure, Tertiary,
pubmed-meshheading:20944213-Pseudomonas aeruginosa
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pubmed:year |
2010
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pubmed:articleTitle |
The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism.
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pubmed:affiliation |
Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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