Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-7-2
pubmed:abstractText
The effects of short-term thymic hormone administration on age-associated immune function were evaluated. Two groups of individuals greater than 65 years of age were treated for 30 days with thymic extracts (TP1) or placebo; before and after this treatment a panel of in vitro and in vivo parameters was determined according to a very rigorous experimental protocol. In most individuals, TP1 treatment was associated with an improvement in cutaneous delayed-type response to PPD. Moreover, an increase in a circulating T cell subpopulation bearing the CD45R surface antigen ("virgin" T cells), and in NK cell cytotoxic activity was also observed in some subjects. Finally, lymphocyte responsiveness to PHA tended to increase, while no effect on lymphocyte ability to produce IL-2 following mitogen stimulation was observed. These findings suggest that TP1 treatment may influence age-related alterations in immune function parameters in some subjects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0394-9532
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-55
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:2094375-Aged, pubmed-meshheading:2094375-Aged, 80 and over, pubmed-meshheading:2094375-Antigens, pubmed-meshheading:2094375-Antigens, Surface, pubmed-meshheading:2094375-Cell Division, pubmed-meshheading:2094375-Cell Membrane, pubmed-meshheading:2094375-Female, pubmed-meshheading:2094375-HLA-DR Antigens, pubmed-meshheading:2094375-Humans, pubmed-meshheading:2094375-Hypersensitivity, Delayed, pubmed-meshheading:2094375-Immune System, pubmed-meshheading:2094375-Immune System Diseases, pubmed-meshheading:2094375-Interleukin-2, pubmed-meshheading:2094375-Killer Cells, Natural, pubmed-meshheading:2094375-Male, pubmed-meshheading:2094375-Mitogens, pubmed-meshheading:2094375-Receptors, Interleukin-2, pubmed-meshheading:2094375-Skin, pubmed-meshheading:2094375-Thymus Hormones, pubmed-meshheading:2094375-Tuberculin
pubmed:year
1990
pubmed:articleTitle
Immune dysfunction in the elderly: effect of thymic hormone administration on several in vivo and in vitro immune function parameters.
pubmed:affiliation
Institute of Internal Medicine, University of Padova, Italy.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial