rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1991-7-2
|
pubmed:abstractText |
The effects of short-term thymic hormone administration on age-associated immune function were evaluated. Two groups of individuals greater than 65 years of age were treated for 30 days with thymic extracts (TP1) or placebo; before and after this treatment a panel of in vitro and in vivo parameters was determined according to a very rigorous experimental protocol. In most individuals, TP1 treatment was associated with an improvement in cutaneous delayed-type response to PPD. Moreover, an increase in a circulating T cell subpopulation bearing the CD45R surface antigen ("virgin" T cells), and in NK cell cytotoxic activity was also observed in some subjects. Finally, lymphocyte responsiveness to PHA tended to increase, while no effect on lymphocyte ability to produce IL-2 following mitogen stimulation was observed. These findings suggest that TP1 treatment may influence age-related alterations in immune function parameters in some subjects.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0394-9532
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
2
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
347-55
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:2094375-Aged,
pubmed-meshheading:2094375-Aged, 80 and over,
pubmed-meshheading:2094375-Antigens,
pubmed-meshheading:2094375-Antigens, Surface,
pubmed-meshheading:2094375-Cell Division,
pubmed-meshheading:2094375-Cell Membrane,
pubmed-meshheading:2094375-Female,
pubmed-meshheading:2094375-HLA-DR Antigens,
pubmed-meshheading:2094375-Humans,
pubmed-meshheading:2094375-Hypersensitivity, Delayed,
pubmed-meshheading:2094375-Immune System,
pubmed-meshheading:2094375-Immune System Diseases,
pubmed-meshheading:2094375-Interleukin-2,
pubmed-meshheading:2094375-Killer Cells, Natural,
pubmed-meshheading:2094375-Male,
pubmed-meshheading:2094375-Mitogens,
pubmed-meshheading:2094375-Receptors, Interleukin-2,
pubmed-meshheading:2094375-Skin,
pubmed-meshheading:2094375-Thymus Hormones,
pubmed-meshheading:2094375-Tuberculin
|
pubmed:year |
1990
|
pubmed:articleTitle |
Immune dysfunction in the elderly: effect of thymic hormone administration on several in vivo and in vitro immune function parameters.
|
pubmed:affiliation |
Institute of Internal Medicine, University of Padova, Italy.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|