Linked Life Data

20943613

Source:http://linkedlifedata.com/resource/pubmed/id/20943613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-10-14
pubmed:abstractText
Staging of non-small-cell lung cancer is a multidisciplinary process involving imaging, endoscopic and surgical techniques. Accuracy is vital in order to avoid false-positive interpretations leading to a false stage III or IV diagnosis in early stage patients, or false-negative findings leading to a false early stage diagnosis in patients with mediastinal lymph node disease. CT scan offers great anatomical detail of tumour spread, but radiological imaging lacks information on the biological nature of the lesions. The latter is brought in by 2-[fluorine-18] fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) scan as a metabolic imaging tool, which, however, has clearly lower spatial resolution. Therefore, contemporary staging relies on the combination of both, preferably in a fusion PET-CT scan. Absence of suspected lymph node metastasis on both CT and PET has a high negative predictive value, and these patients may in general proceed to surgery. In most others, tissue confirmation of the locoregional lymph node status is needed. The historical standard of mediastinoscopy is nowadays complemented by endoscopic techniques by the bronchial or esophageal approach. Each of these techniques remains important in modern staging algorithms. A practical scheme for rational staging in clinical practice is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1569-8041
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
21 Suppl 7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
vii189-95
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Early stage non-small-cell lung cancer: challenges in staging and adjuvant treatment: evidence-based staging.
pubmed:affiliation
Respiratory Oncology Unit Pulmonology, University Hospital Gasthuisberg, Leuven, Belgium. johan.vansteenkiste@uzleuven.be
pubmed:publicationType
Journal Article, Review