| pubmed-article:20943391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0002482 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0378796 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0034423 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:20943391 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:20943391 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:20943391 | pubmed:dateCreated | 2010-10-19 | lld:pubmed |
| pubmed-article:20943391 | pubmed:abstractText | Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical vein endothelial cells (HUVEC) in vitro. Compound 6 (5-chloro-2-hydroxy-N-(quinolin-8-yl)benzamide) exhibited the most potent inhibitory activity (IC(50)=3.8 and 5.5 nM for VEGFR-2 kinase and HUVEC, respectively). Docking simulation supported the initial pharmacophoric hypothesis and suggested a common mode of interaction at the ATP-binding site of VEGFR-2, which demonstrates that compound 6 is a potential agent for cancer therapy deserving further researching. | lld:pubmed |
| pubmed-article:20943391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20943391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20943391 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20943391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20943391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20943391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20943391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20943391 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20943391 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:20943391 | pubmed:author | pubmed-author:ShiLeiL | lld:pubmed |
| pubmed-article:20943391 | pubmed:author | pubmed-author:YangYingY | lld:pubmed |
| pubmed-article:20943391 | pubmed:author | pubmed-author:ZhouYangY | lld:pubmed |
| pubmed-article:20943391 | pubmed:author | pubmed-author:ZhuHai-LiangH... | lld:pubmed |
| pubmed-article:20943391 | pubmed:author | pubmed-author:LiHuan-QiuHQ | lld:pubmed |
| pubmed-article:20943391 | pubmed:author | pubmed-author:ZhuZhen-WeiZW | lld:pubmed |
| pubmed-article:20943391 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20943391 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20943391 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20943391 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:20943391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20943391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20943391 | pubmed:pagination | 6653-6 | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:meshHeading | pubmed-meshheading:20943391... | lld:pubmed |
| pubmed-article:20943391 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20943391 | pubmed:articleTitle | Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. | lld:pubmed |
| pubmed-article:20943391 | pubmed:affiliation | State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. | lld:pubmed |
| pubmed-article:20943391 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20943391 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20943391 | lld:chembl |
