Source:http://linkedlifedata.com/resource/pubmed/id/20943391
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
22
|
pubmed:dateCreated |
2010-10-19
|
pubmed:abstractText |
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical vein endothelial cells (HUVEC) in vitro. Compound 6 (5-chloro-2-hydroxy-N-(quinolin-8-yl)benzamide) exhibited the most potent inhibitory activity (IC(50)=3.8 and 5.5 nM for VEGFR-2 kinase and HUVEC, respectively). Docking simulation supported the initial pharmacophoric hypothesis and suggested a common mode of interaction at the ATP-binding site of VEGFR-2, which demonstrates that compound 6 is a potential agent for cancer therapy deserving further researching.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
1464-3405
|
pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:day |
15
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
6653-6
|
pubmed:meshHeading |
pubmed-meshheading:20943391-Amides,
pubmed-meshheading:20943391-Cells, Cultured,
pubmed-meshheading:20943391-Drug Design,
pubmed-meshheading:20943391-Humans,
pubmed-meshheading:20943391-Inhibitory Concentration 50,
pubmed-meshheading:20943391-Models, Molecular,
pubmed-meshheading:20943391-Quinolines,
pubmed-meshheading:20943391-Vascular Endothelial Growth Factor Receptor-2
|
pubmed:year |
2010
|
pubmed:articleTitle |
Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors.
|
pubmed:affiliation |
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|