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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-11-24
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pubmed:abstractText |
Interleukin-6 (IL-6) is a proinflammatory cytokine that increases early in the serum of patients with acute kidney injury (AKI). The aim of this study was to determine whether urine IL-6 is an early biomarker of AKI and determine the source of urine IL-6. Numerous proteins, including cytokines, are filtered by the glomerulus and then endocytosed and metabolized by the proximal tubule. Since proximal tubule injury is a hallmark of AKI, we hypothesized that urine IL-6 would increase in AKI due to impaired proximal tubule metabolism of filtered IL-6.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1466-609X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R181
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pubmed:meshHeading |
pubmed-meshheading:20942931-Acute Kidney Injury,
pubmed-meshheading:20942931-Adolescent,
pubmed-meshheading:20942931-Animals,
pubmed-meshheading:20942931-Biological Markers,
pubmed-meshheading:20942931-Cardiac Surgical Procedures,
pubmed-meshheading:20942931-Child,
pubmed-meshheading:20942931-Child, Preschool,
pubmed-meshheading:20942931-Female,
pubmed-meshheading:20942931-Humans,
pubmed-meshheading:20942931-Infant,
pubmed-meshheading:20942931-Infant, Newborn,
pubmed-meshheading:20942931-Interleukin-6,
pubmed-meshheading:20942931-Male,
pubmed-meshheading:20942931-Mice,
pubmed-meshheading:20942931-Mice, Inbred C57BL,
pubmed-meshheading:20942931-Postoperative Complications,
pubmed-meshheading:20942931-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery.
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pubmed:affiliation |
Department of Medicine, Division of Nephrology, Denver Health & Hospitals, 777 Bannock Street, Denver, CO 80204, USA. Paula.Dennen@UCDenver.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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