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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0017262,
umls-concept:C0026809,
umls-concept:C0039337,
umls-concept:C0185117,
umls-concept:C0205094,
umls-concept:C0205095,
umls-concept:C0335038,
umls-concept:C0443199,
umls-concept:C1412805,
umls-concept:C2911684
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pubmed:dateCreated |
2010-11-1
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pubmed:abstractText |
Bone Morphogenetic Protein 4 (BMP4) is a diffusible factor which regulates embryonic taste organ development. However, the role of BMP4 in taste buds of adult mice is unknown. We utilized transgenic mice with LacZ under the control of the BMP4 promoter to reveal the expression of BMP4 in the tongues of adult mice. Further we evaluate the pattern of BMP4 expression with that of markers of specific taste bud cell types and cell proliferation to define and compare the cell populations expressing BMP4 in anterior (fungiform papillae) and posterior (circumvallate papilla) tongue.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2202
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129
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pubmed:meshHeading |
pubmed-meshheading:20942907-Alleles,
pubmed-meshheading:20942907-Animals,
pubmed-meshheading:20942907-Antimetabolites,
pubmed-meshheading:20942907-Bone Morphogenetic Protein 4,
pubmed-meshheading:20942907-Bromodeoxyuridine,
pubmed-meshheading:20942907-Cell Cycle,
pubmed-meshheading:20942907-Cell Differentiation,
pubmed-meshheading:20942907-Cell Proliferation,
pubmed-meshheading:20942907-Epithelial Cells,
pubmed-meshheading:20942907-Fluorescent Antibody Technique,
pubmed-meshheading:20942907-Genes, Reporter,
pubmed-meshheading:20942907-Lac Operon,
pubmed-meshheading:20942907-Mice,
pubmed-meshheading:20942907-Mice, Transgenic,
pubmed-meshheading:20942907-SOXB1 Transcription Factors,
pubmed-meshheading:20942907-Taste Buds
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pubmed:year |
2010
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pubmed:articleTitle |
Differential expression of a BMP4 reporter allele in anterior fungiform versus posterior circumvallate taste buds of mice.
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pubmed:affiliation |
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Denver, School of Medicine, Aurora, Colorado 80045, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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