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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-1-13
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pubmed:abstractText |
Severe acute pancreatitis (SAP) is characterized by trypsinogen activation, infiltration of leucocytes and tissue necrosis but the intracellular signalling mechanisms regulating organ injury in the pancreas remain elusive. Rho-kinase is a potent regulator of specific cellular processes effecting several pro-inflammatory activities. Herein, we examined the role of Rho-kinase signalling in acute pancreatitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Amylases,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Cholagogues and Choleretics,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Taurocholic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Y 27632,
http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
648-58
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pubmed:meshHeading |
pubmed-meshheading:20942858-Amides,
pubmed-meshheading:20942858-Amylases,
pubmed-meshheading:20942858-Animals,
pubmed-meshheading:20942858-Chemokine CXCL2,
pubmed-meshheading:20942858-Cholagogues and Choleretics,
pubmed-meshheading:20942858-Enzyme Inhibitors,
pubmed-meshheading:20942858-Flow Cytometry,
pubmed-meshheading:20942858-Male,
pubmed-meshheading:20942858-Mice,
pubmed-meshheading:20942858-Mice, Inbred C57BL,
pubmed-meshheading:20942858-Necrosis,
pubmed-meshheading:20942858-Neutrophil Infiltration,
pubmed-meshheading:20942858-Pancreas,
pubmed-meshheading:20942858-Pancreatitis,
pubmed-meshheading:20942858-Peroxidase,
pubmed-meshheading:20942858-Pyridines,
pubmed-meshheading:20942858-Signal Transduction,
pubmed-meshheading:20942858-Taurocholic Acid,
pubmed-meshheading:20942858-Trypsinogen,
pubmed-meshheading:20942858-rho-Associated Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
Rho-kinase signalling regulates trypsinogen activation and tissue damage in severe acute pancreatitis.
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pubmed:affiliation |
Department of Surgery, Malmö University Hospital, Lund University, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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