Linked Life Data

20942648

Source:http://linkedlifedata.com/resource/pubmed/id/20942648

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-19
pubmed:abstractText
Staphylococcus aureus organisms vary in the function of the staphylococcal virulence regulator gene agr. To test for a relationship between agr and transmission in S. aureus, we determined the prevalence and genetic basis of agr dysfunction among nosocomial methicillin-resistant S. aureus (MRSA) in an area of MRSA endemicity. Identical inactivating agr mutations were not detected in epidemiologically unlinked clones within or between hospitals. Additionally, most agr mutants had single mutations, indicating that they were short lived. Collectively, the results suggest that agr dysfunction is adaptive for survival in the infected host but that it may be counteradaptive outside infected host tissues.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1537-6613
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1593-9
pubmed:dateRevised
2011-1-21
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Mutations in agr do not persist in natural populations of methicillin-resistant Staphylococcus aureus.
pubmed:affiliation
Department of Medicine, Division of Infectious Diseases, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. shopsin@saturn.med.nyu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural