Linked Life Data

20941704

Source:http://linkedlifedata.com/resource/pubmed/id/20941704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-10-13
pubmed:abstractText
By transplanting human hematopoietic stem and progenitor cells in newborn immunodeficient mice, researchers have recently achieved development of a human adaptive immune system, consisting of B cells, T cells, dendritic cells, and some cells of the myeloid lineage, which together form respective structured lymphoid organs as thymus, spleen, and lymph nodes, and produce some functional immune responses. These will provide valuable models to analyze the impact of chemicals, pharmaceuticals, or species-specific infections on human hematolymphoid cells in vivo. This unit describes methods for isolation of the progenitor human cells and their injection into mouse to constitute an adaptive immune system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1934-9262
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
Chapter 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
Unit2.13
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Mouse models for human hemato-lymphopoiesis.
pubmed:affiliation
Institute for Research in Biomedicine, Bellinzona, Switzerland.
pubmed:publicationType
Journal Article