|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
2010-10-13
|
|
pubmed:abstractText |
Pouchitis and Crohn's-like complications can plague patients after IPAA. NOD2 is an intracellular sensor for bacterial cell wall peptidoglycan. NOD2 mutations compromise host response to enteric bacteria and are increased in Crohn's disease. We hypothesize that IPAA patients with complications (Crohn's disease-like/pouchitis) have a higher rate of NOD2 mutations compared with asymptomatic IPAA patients.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1530-0358
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
53
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1487-94
|
|
pubmed:meshHeading |
pubmed-meshheading:20940596-Anastomosis, Surgical,
pubmed-meshheading:20940596-Case-Control Studies,
pubmed-meshheading:20940596-Chi-Square Distribution,
pubmed-meshheading:20940596-Colitis, Ulcerative,
pubmed-meshheading:20940596-Colonic Pouches,
pubmed-meshheading:20940596-Female,
pubmed-meshheading:20940596-Genotype,
pubmed-meshheading:20940596-Humans,
pubmed-meshheading:20940596-Male,
pubmed-meshheading:20940596-Mutation,
pubmed-meshheading:20940596-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:20940596-Polymerase Chain Reaction,
pubmed-meshheading:20940596-Polymorphism, Single Nucleotide,
pubmed-meshheading:20940596-Postoperative Complications,
pubmed-meshheading:20940596-Pouchitis,
pubmed-meshheading:20940596-Proctocolectomy, Restorative,
pubmed-meshheading:20940596-Retrospective Studies,
pubmed-meshheading:20940596-Severity of Illness Index
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.
|
|
pubmed:affiliation |
Division of Colon and Rectal Surgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033-0850, USA. rsehgal@hmc.psu.edu
|
|
pubmed:publicationType |
Journal Article
|
