Linked Life Data

20940256

Source:http://linkedlifedata.com/resource/pubmed/id/20940256

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 21
pubmed:dateCreated
2010-10-25
pubmed:abstractText
In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue repair, but their tissue-specific role in this process is poorly understood. Here, we show that mice containing a fibroblast-specific deletion of integrin ?1 exhibit delayed cutaneous wound closure and less granulation tissue formation, including reduced production of new ECM and reduced expression of ?-smooth muscle actin (?-SMA). Integrin-?1-deficient fibroblasts showed reduced expression of type I collagen and connective tissue growth factor, and failed to differentiate into myofibroblasts as a result of reduced ?-SMA stress fiber formation. Loss of integrin ?1 in adult fibroblasts reduced their ability to adhere to, to spread on and to contract ECM. Within stressed collagen matrices, integrin-?1-deficient fibroblasts showed reduced activation of latent TGF?. Addition of active TGF? alleviated the phenotype of integrin-?1-deficient mice. Thus integrin ?1 is essential for normal wound healing, where it acts, at least in part, through a TGF?-dependent mechanism in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1477-9137
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3674-82
pubmed:dateRevised
2011-7-15
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo.
pubmed:affiliation
The Canadian Institute of Health Research Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Dental Sciences Building, London, ON N6A 5C1, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't