Linked Life Data

20939093

Source:http://linkedlifedata.com/resource/pubmed/id/20939093

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-25
pubmed:abstractText
Brown adipose tissue and white adipose tissue depots are noninvasively characterized in vitro and in vivo in healthy and obese mice using intermolecular zero-quantum coherence transitions between lipid and water spins. Intermolecular zero-quantum coherences enable selective detection of spatial correlation between water and lipid spins and thereby the hydration of fatty deposits with subvoxel resolution. At about a 100 mm distance scale, the major observed peaks are between water, methylene protons at 1.3 ppm, and olefinic protons at 5.3 ppm. Our in vitro results show that the methylene-olefinic intermolecular zero-quantum coherence signal is strong both in brown and white adipose tissues, but that the water-methylene intermolecular zero-quantum coherence signal is characteristic only of brown adipose tissue. In vivo, the ratio of these peaks is substantially higher in lean or young mice than in old or obese mice.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1522-2594
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Wiley-Liss, Inc.
pubmed:issnType
Electronic
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
313-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
In vivo brown adipose tissue detection and characterization using water-lipid intermolecular zero-quantum coherences.
pubmed:affiliation
Center for Molecular and Biomolecular Imaging, 2220 French Family Science Center, Duke University, Chemistry Department, Durham, North Carolina 27708-0346, USA. rtb9@duke.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural