|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021655,
umls-concept:C0026845,
umls-concept:C0033684,
umls-concept:C0037083,
umls-concept:C0086418,
umls-concept:C0205263,
umls-concept:C0206131,
umls-concept:C0213321,
umls-concept:C0333348,
umls-concept:C1327616,
umls-concept:C1710082,
umls-concept:C2346714
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2011-6-14
|
|
pubmed:abstractText |
Pigment epithelium-derived factor (PEDF) is a multifunctional protein with neurotrophic and anti-angiogenic properties. More recently it became evident that PEDF is upregulated in patients with type 2 diabetes and also contributes to insulin resistance in mice. During characterization of the secretome of in vitro differentiated human adipocytes by two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ionization-MS, we found that PEDF is one of the most abundant proteins released by adipocytes. The aim of this study was to investigate the regulation and autocrine function of PEDF in human adipocytes and to determine its paracrine effects on human skeletal muscle cells (hSkMC) and human smooth muscle cells (hSMC).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1476-5497
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
762-72
|
|
pubmed:meshHeading |
pubmed-meshheading:20938440-Adipocytes,
pubmed-meshheading:20938440-Adipogenesis,
pubmed-meshheading:20938440-Animals,
pubmed-meshheading:20938440-Autocrine Communication,
pubmed-meshheading:20938440-Eye Proteins,
pubmed-meshheading:20938440-Female,
pubmed-meshheading:20938440-Humans,
pubmed-meshheading:20938440-Immunohistochemistry,
pubmed-meshheading:20938440-Inflammation,
pubmed-meshheading:20938440-Insulin Resistance,
pubmed-meshheading:20938440-Male,
pubmed-meshheading:20938440-Mice,
pubmed-meshheading:20938440-Muscle Cells,
pubmed-meshheading:20938440-Myocytes, Smooth Muscle,
pubmed-meshheading:20938440-NF-kappa B,
pubmed-meshheading:20938440-Nerve Growth Factors,
pubmed-meshheading:20938440-Obesity,
pubmed-meshheading:20938440-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20938440-Serpins,
pubmed-meshheading:20938440-Up-Regulation
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells.
|
|
pubmed:affiliation |
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Düsseldorf, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
