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rdf:type |
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lifeskim:mentions |
umls-concept:C0003483,
umls-concept:C0035820,
umls-concept:C0041904,
umls-concept:C0086418,
umls-concept:C0162871,
umls-concept:C0183683,
umls-concept:C0215848,
umls-concept:C0242184,
umls-concept:C0542279,
umls-concept:C0623362,
umls-concept:C0812201,
umls-concept:C1135918,
umls-concept:C1822686,
umls-concept:C2348110,
umls-concept:C2348977
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-11
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pubmed:abstractText |
We sought to determine whether hypoxia is an initiating factor in the matrix metalloproteinase-2 (MMP-2) up-regulation observed in abdominal aortic aneurysm (AAA) and whether hypoxia-inducible factor-1? (HIF-1?) or Ets-1 are mediating factors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ETS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases, Secreted,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-ets-1,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0135
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-70
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pubmed:meshHeading |
pubmed-meshheading:20938207-Anoxia,
pubmed-meshheading:20938207-Aortic Aneurysm, Abdominal,
pubmed-meshheading:20938207-Humans,
pubmed-meshheading:20938207-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:20938207-Matrix Metalloproteinase 2,
pubmed-meshheading:20938207-Matrix Metalloproteinase 9,
pubmed-meshheading:20938207-Matrix Metalloproteinases, Secreted,
pubmed-meshheading:20938207-Myocytes, Smooth Muscle,
pubmed-meshheading:20938207-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:20938207-RNA, Messenger,
pubmed-meshheading:20938207-Up-Regulation
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pubmed:year |
2011
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pubmed:articleTitle |
Hypoxia in abdominal aortic aneurysm supports a role for HIF-1? and Ets-1 as drivers of matrix metalloproteinase upregulation in human aortic smooth muscle cells.
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pubmed:affiliation |
Department for Health, University of Bath, Bath, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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