Linked Life Data

20936232

Source:http://linkedlifedata.com/resource/pubmed/id/20936232

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2010-11-25
pubmed:abstractText
Different nitronaphthylbutadienes have been previously proved to have antitumour activity. The main drawback of these derivatives is their low water solubility. With the aim of facilitating the administration of these new drugs we have synthesized the hexyl (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate analogue (1-Naph-NHCB) which is demonstrated to be easily included into cyclodextrins and/or entrapped into liposomes. Its antitumour activity was revealed to be almost comparable with that of the previously studied methyl analogue ester (1-Naph-NMCB). On the other hand, in vitro studies with different cancer cell lines showed that the cytotoxic activity of both 1-Naph-NMCB and 1-Naph-NHCB were fully preserved and in some cases also enhanced when entrapped into liposomal carriers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1477-0539
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5674-81
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Strategies for improving the water solubility of new antitumour nitronaphthylbutadiene derivatives.
pubmed:affiliation
Dipartimento di Scienze del Farmaco, Università'G. d'Annunzio', Via dei Vestini 31, Chieti, 66013, Italy. fontana@unich.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't