Source:http://linkedlifedata.com/resource/pubmed/id/20935070
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-11-25
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| pubmed:abstractText |
The authors characterized human immunodeficiency virus (HIV) and hepatitis C virus (HCV) incidence and prospective changes in self-reported risk behavior over 2 years among 1,158 injection drug users (IDUs) recruited in Chennai, India, in 2005-2006. At baseline, HIV prevalence was 25.3%, and HCV prevalence was 54.5%. Seropositive persons with prevalent HIV infection were used to estimate baseline HIV incidence by means of the Calypte HIV-1 BED Incidence EIA (Calypte Biomedical Corporation, Portland, Oregon). Longitudinal HIV and HCV incidence were measured among 865 HIV-negative IDUs and 519 HCV antibody-negative IDUs followed semiannually for 2 years. Participants received pre- and posttest risk reduction counseling at each visit. Estimated HIV incidence at baseline was 2.95 per 100 person-years (95% confidence interval (CI): 1.21, 4.69) by BED assay; observed HIV incidence over 1,262 person-years was 0.48 per 100 person-years (95% CI: 0.17, 1.03). HCV incidence over 645 person-years was 1.71 per 100 person-years (95% CI: 0.85, 3.03). Self-reported risk behaviors declined significantly over time, from 100% of participants reporting drug injection at baseline to 11% at 24 months. In this cohort with high HIV and HCV prevalence at enrollment, the authors observed low incidence and declining self-reported risk behavior over time. While no formal intervention was administered, these findings highlight the potential impact of voluntary counseling and testing in a high-risk cohort.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
|
| pubmed:issn |
1476-6256
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| pubmed:author |
pubmed-author:CelentanoDavid DDD,
pubmed-author:IqbalSyed HSH,
pubmed-author:KumarMuniratnam SureshMS,
pubmed-author:LatkinCarlC,
pubmed-author:MehtaShruti HSH,
pubmed-author:MurugavelKalilapuri GKG,
pubmed-author:SanthanamAnandA,
pubmed-author:SolomonSunil SuhasSS,
pubmed-author:SolomonSunitiS,
pubmed-author:SrikrishnanAylur KAK,
pubmed-author:VasudevanCanjeevaram KCK
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| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
172
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1259-67
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| pubmed:dateRevised |
2011-1-26
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| pubmed:meshHeading |
pubmed-meshheading:20935070-Adult,
pubmed-meshheading:20935070-Alcohol Drinking,
pubmed-meshheading:20935070-Cohort Studies,
pubmed-meshheading:20935070-Comorbidity,
pubmed-meshheading:20935070-Confidence Intervals,
pubmed-meshheading:20935070-Drug Users,
pubmed-meshheading:20935070-Follow-Up Studies,
pubmed-meshheading:20935070-HIV Infections,
pubmed-meshheading:20935070-Hepatitis C,
pubmed-meshheading:20935070-Humans,
pubmed-meshheading:20935070-Incidence,
pubmed-meshheading:20935070-India,
pubmed-meshheading:20935070-Longitudinal Studies,
pubmed-meshheading:20935070-Male,
pubmed-meshheading:20935070-Population Surveillance,
pubmed-meshheading:20935070-Questionnaires,
pubmed-meshheading:20935070-Risk-Taking,
pubmed-meshheading:20935070-Substance Abuse, Intravenous
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| pubmed:year |
2010
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| pubmed:articleTitle |
Low incidences of human immunodeficiency virus and hepatitis C virus infection and declining risk behaviors in a cohort of injection drug users in Chennai, India.
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| pubmed:affiliation |
Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|