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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-11-24
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pubmed:abstractText |
A mouse and human brain-enriched micro-RNA-146a (miRNA-146a) is known to be important in modulating the innate immune response and inflammatory signaling in certain immunological and brain cell types. In this study we examined miRNA-146a levels in early-, moderate- and late-stage Alzheimer's disease (AD) neocortex and hippocampus, in several human primary brain and retinal cell lines, and in 5 different transgenic mouse models of AD including Tg2576, TgCRND8, PSAPP, 3xTg-AD and 5xFAD. Inducible expression of miRNA-146a was found to be significantly up-regulated in a primary co-culture of human neuronal-glial (HNG) cells stressed using interleukin1-beta (IL-1?), and this up-regulation was quenched using specific NF-?B inhibitors including curcumin. Expression of miRNA-146a correlated with senile plaque density and synaptic pathology in Tg2576 and in 5xFAD transgenic mouse models used in the study of this common neurodegenerative disorder.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1872-7972
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
487
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
94-8
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pubmed:dateRevised |
2011-3-29
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pubmed:meshHeading |
pubmed-meshheading:20934487-Age Factors,
pubmed-meshheading:20934487-Alzheimer Disease,
pubmed-meshheading:20934487-Amyloid beta-Protein Precursor,
pubmed-meshheading:20934487-Animals,
pubmed-meshheading:20934487-Cell Line, Transformed,
pubmed-meshheading:20934487-Disease Models, Animal,
pubmed-meshheading:20934487-Enzyme Inhibitors,
pubmed-meshheading:20934487-Hippocampus,
pubmed-meshheading:20934487-Humans,
pubmed-meshheading:20934487-Mice,
pubmed-meshheading:20934487-Mice, Transgenic,
pubmed-meshheading:20934487-MicroRNAs,
pubmed-meshheading:20934487-Mutation,
pubmed-meshheading:20934487-Neocortex,
pubmed-meshheading:20934487-Presenilin-1,
pubmed-meshheading:20934487-Transfection,
pubmed-meshheading:20934487-Up-Regulation,
pubmed-meshheading:20934487-tau Proteins
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pubmed:year |
2011
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pubmed:articleTitle |
Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models.
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pubmed:affiliation |
LSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112-2272, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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