Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-12-21
pubmed:abstractText
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that alters cortical excitability and activity in a polarity-dependent way. Stimulation for a few minutes has been shown to induce plastic alterations of cortical excitability and to improve cognitive performance. These effects might be related to stimulation-induced alterations of functional cortical network connectivity. We aimed to investigate the impact of tDCS on cortical network function by functional connectivity and graph theoretical analysis of the BOLD fMRI spontaneous activity. fMRI resting-state datasets were acquired immediately before and after 10-min bipolar tDCS during rest, with the anode placed over the left primary motor cortex (M1) and the cathode over the contralateral frontopolar cortex. For each dataset, grey matter voxel-based synchronization matrices were calculated and thresholded to construct undirected graphs. Nodal connectivity degree and minimum path length maps were calculated and compared before and after tDCS. Nodal minimum path lengths significantly increased in the left somatomotor (SM1) cortex after anodal tDCS, which means that the number of direct functional connections from the left SM1 to topologically distant grey matter voxels significantly decreased. In contrast, functional coupling between premotor and superior parietal areas with the left SM1 significantly increased. Additionally, the nodal connectivity degree in the left posterior cingulate cortex (PCC) area as well as in the right dorsolateral prefrontal cortex (right DLPFC) significantly increased. In summary, we provide initial support that tDCS-induced neuroplastic alterations might be related to functional connectivity changes in the human brain. Additionally, we propose our approach as a powerful method to track for neuroplastic changes in the human brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1095-9572
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2287-96
pubmed:meshHeading
pubmed-meshheading:20932916-Adult, pubmed-meshheading:20932916-Algorithms, pubmed-meshheading:20932916-Brain, pubmed-meshheading:20932916-Cluster Analysis, pubmed-meshheading:20932916-Data Interpretation, Statistical, pubmed-meshheading:20932916-Electric Stimulation, pubmed-meshheading:20932916-Female, pubmed-meshheading:20932916-Functional Laterality, pubmed-meshheading:20932916-Humans, pubmed-meshheading:20932916-Image Processing, Computer-Assisted, pubmed-meshheading:20932916-Magnetic Resonance Imaging, pubmed-meshheading:20932916-Male, pubmed-meshheading:20932916-Monte Carlo Method, pubmed-meshheading:20932916-Motor Cortex, pubmed-meshheading:20932916-Neural Pathways, pubmed-meshheading:20932916-Neuronal Plasticity, pubmed-meshheading:20932916-Oxygen, pubmed-meshheading:20932916-Prefrontal Cortex, pubmed-meshheading:20932916-Psychomotor Performance, pubmed-meshheading:20932916-Rest, pubmed-meshheading:20932916-Somatosensory Cortex, pubmed-meshheading:20932916-Transcranial Magnetic Stimulation, pubmed-meshheading:20932916-Young Adult
pubmed:year
2011
pubmed:articleTitle
Introducing graph theory to track for neuroplastic alterations in the resting human brain: a transcranial direct current stimulation study.
pubmed:affiliation
Department of Clinical Neurophysiology, Georg-August University of Göttingen, Göttingen, Germany. rafael.polania@med.uni-goettingen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't