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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-10-22
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pubmed:abstractText |
Around 20% of breast cancers (BC) show ERBB2 gene amplification and overexpression of the ERBB2 tyrosine kinase receptor. They are associated with a poor prognosis but can benefit from targeted therapy. A better knowledge of these BCs, genomically and biologically heterogeneous, may help understand their behavior and design new therapeutic strategies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
pubmed-author:AdélaïdeJoséJ,
pubmed-author:BekhoucheIsmahaneI,
pubmed-author:Ben AyedFarhatF,
pubmed-author:Ben HamidaAzzaA,
pubmed-author:BertucciFrançoisF,
pubmed-author:BirnbaumDanielD,
pubmed-author:BonanseaJulienJ,
pubmed-author:ChaffanetMaxM,
pubmed-author:Charafe-JauffretEmmanuelleE,
pubmed-author:FinettiPascalP,
pubmed-author:InnocentiCharlèneC,
pubmed-author:JacquemierJocelyneJ,
pubmed-author:RaynaudStéphaneS,
pubmed-author:SircoulombFabriceF,
pubmed-author:TarpinCaroleC,
pubmed-author:ViensPatriceP
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
539
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pubmed:meshHeading |
pubmed-meshheading:20932292-Adenocarcinoma,
pubmed-meshheading:20932292-Breast Neoplasms,
pubmed-meshheading:20932292-Cell Line, Tumor,
pubmed-meshheading:20932292-Cohort Studies,
pubmed-meshheading:20932292-Female,
pubmed-meshheading:20932292-Gene Expression Profiling,
pubmed-meshheading:20932292-Genome, Human,
pubmed-meshheading:20932292-Humans,
pubmed-meshheading:20932292-Immunohistochemistry,
pubmed-meshheading:20932292-In Situ Hybridization, Fluorescence,
pubmed-meshheading:20932292-Nucleic Acid Hybridization,
pubmed-meshheading:20932292-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20932292-Phosphorylation,
pubmed-meshheading:20932292-Receptor, erbB-2,
pubmed-meshheading:20932292-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Genome profiling of ERBB2-amplified breast cancers.
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pubmed:affiliation |
Marseille Cancer Research Center, UMR891 Inserm, Institut Paoli-Calmettes, Department of Molecular Oncology, Marseille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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