Linked Life Data

2093021

Source:http://linkedlifedata.com/resource/pubmed/id/2093021

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1991-6-17
pubmed:abstractText
Ortho-cresol (o-cresol) produces a modifying influence on the effect produced by benz/a/pyrene (BP) under mice CC57B exposure to the combined peroral administration of the two chemicals. A low-toxic dose of o-cresol (Img) abruptly activates the effect of the same dose of BP (1 mg) according to all parameters (increase of the frequency, coefficient of multiplicity and degree of malignancy of tumours, shortening of the latency period) and somewhat inhibits its activity when administered before or after BP. Simultaneous administration of o-cresol in a ++super-toxic dose (10 mg) and BP in an optimal dose (5 mg) does not change the frequency of tumours, as compared to the control, however, inhibits the progression of induces neoplasms, which is manifest in the decrease of the frequency of malignancy, multiplicity of appearance and lengthening of the time of the onset of their malignization. Simultaneous administration of o-cresol in the dose relevant to the MAC for water does not change the carcinogenic activity of BP, which testifies to the necessity of sanitary control of observing hygienic regulations for both chemicals, as the most effective measure of prophylaxis of the malignant tumours morbidity of the population.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0016-9900
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Experimental study of combined effects of benzo(a)pyrene and ortho-cresol on the body].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract