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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
Multiple meningiomas occur in <10% of meningioma patients. Their development may be caused by the presence of a predisposing germline mutation in the neurofibromatosis type 2 (NF2) gene. The predisposing gene in patients with non-NF2 associated multiple meningiomas remains to be identified. Recently, SMARCB1 was reported to be a potential predisposing gene for multiple meningiomas in a family with schwannomatosis and multiple meningiomas. However, involvement of this gene in the development of the meningiomas was not demonstrated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1468-6244
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-7
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pubmed:meshHeading |
pubmed-meshheading:20930055-Base Sequence,
pubmed-meshheading:20930055-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:20930055-DNA Mutational Analysis,
pubmed-meshheading:20930055-DNA Primers,
pubmed-meshheading:20930055-DNA-Binding Proteins,
pubmed-meshheading:20930055-Female,
pubmed-meshheading:20930055-Genes, Neurofibromatosis 2,
pubmed-meshheading:20930055-Genotype,
pubmed-meshheading:20930055-Germ-Line Mutation,
pubmed-meshheading:20930055-Humans,
pubmed-meshheading:20930055-Male,
pubmed-meshheading:20930055-Meningioma,
pubmed-meshheading:20930055-Microsatellite Repeats,
pubmed-meshheading:20930055-Molecular Sequence Data,
pubmed-meshheading:20930055-Mutation, Missense,
pubmed-meshheading:20930055-Pedigree,
pubmed-meshheading:20930055-Transcription Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Germline SMARCB1 mutation and somatic NF2 mutations in familial multiple meningiomas.
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pubmed:affiliation |
Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Case Reports
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