Linked Life Data

20929672

Source:http://linkedlifedata.com/resource/pubmed/id/20929672

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-8
pubmed:abstractText
Mitochondria are dynamic organelles that continuously move, fuse and divide. Their overall morphology, ranging from a filamentous network to a collection of isolated dots, is determined by fusion-fission equilibrium, which depends on the cellular and physiological context. The machineries of fusion and fission, that are conserved throughout evolution, include three large GTPases of the dynamin-superfamily: Dnm1/DRP1 - involved in fission - as well as Fzo1/MFN and Mgm1/OPA1 - required for fusion. While the activities, mecanisms and regulations of mitochondrial fusion and fission machineries continue to be unravelled, the relevance of mitochondrial dynamics is witnessed by their impact on organelle functions, cell survival and cell differenciation, their requirement for embryonic development and their involvement in neurological diseases.
pubmed:commentsCorrections
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0767-0974
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
823-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Mitochondrial morphology and dynamics: actors, mechanisms and functions].
pubmed:affiliation
Institut de biochimie et génétique cellulaires (IBGC), UMR 5095 CNRS/ Université Victor Segalen, 1, rue Camille Saint-Saëns, 33077 Bordeaux Cedex, France.
pubmed:publicationType
Journal Article, English Abstract, Review