Linked Life Data

2092950

Source:http://linkedlifedata.com/resource/pubmed/id/2092950

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1991-6-18
pubmed:abstractText
1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time course and amplitude of effect similar to that of indomethacin, although the potency was only about 4% of that for indomethacin. 3. When ethamsylate and indomethacin were co-administered they did not show additive effects, suggesting that they do not share a common mode of action. It is proposed that ethamsylate, like indomethacin, may inhibit prostaglandin synthesis. Ulceration produced by indomethacin, it is suggested that it may prove to be a useful addition to, or replacement for, indomethacin in the treatment of inflammatory disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0305-1870
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
821-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin.
pubmed:affiliation
Department of Pharmacy, Brighton Polytechnic, East Sussex, UK.
pubmed:publicationType
Journal Article, Comparative Study