Linked Life Data

20929336

Source:http://linkedlifedata.com/resource/pubmed/id/20929336

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-10-29
pubmed:abstractText
The oral and central nervous systems (CNS) present a unique set of barriers to the delivery of important diagnostic and therapeutic agents. Extensive research over the past few years has enabled a better understanding of these physical and biological barriers based on tight cellular junctions and expression of active transporters and metabolizing enzymes at the luminal surfaces of the gastrointestinal (GI) tract and the blood-brain barrier (BBB). This review focuses on the recent understanding of transport across the GI tract and BBB and the development of nanotechnology-based delivery strategies that can enhance bioavailability of drugs. Multifunctional lipid nanosystems, such as oil-in-water nanoemulsions, that integrate enhancement in permeability, tissue and cell targeting, imaging, and therapeutic functions are especially promising. Based on strategic choice of edible oils, surfactants and additional surface modifiers, and different types of payloads, rationale design of multifunctional nanoemulsions can serve as a safe and effective delivery vehicle across oral and CNS barriers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1464-5203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
260-73
pubmed:meshHeading
pubmed-meshheading:20929336-Administration, Oral, pubmed-meshheading:20929336-Animals, pubmed-meshheading:20929336-Biological Availability, pubmed-meshheading:20929336-Biological Transport, pubmed-meshheading:20929336-Blood-Brain Barrier, pubmed-meshheading:20929336-Brain, pubmed-meshheading:20929336-Cell Membrane Permeability, pubmed-meshheading:20929336-Central Nervous System Agents, pubmed-meshheading:20929336-Cytochrome P-450 Enzyme System, pubmed-meshheading:20929336-Drug Carriers, pubmed-meshheading:20929336-Drug Delivery Systems, pubmed-meshheading:20929336-Emulsions, pubmed-meshheading:20929336-Gastrointestinal Tract, pubmed-meshheading:20929336-Humans, pubmed-meshheading:20929336-Nanotechnology, pubmed-meshheading:20929336-P-Glycoprotein, pubmed-meshheading:20929336-Tight Junctions
pubmed:year
2010
pubmed:articleTitle
A review of multifunctional nanoemulsion systems to overcome oral and CNS drug delivery barriers.
pubmed:affiliation
Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Review