Linked Life Data

20927381

Source:http://linkedlifedata.com/resource/pubmed/id/20927381

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-10-7
pubmed:abstractText
The GXGD-type diaspartyl intramembrane protease, presenilin, constitutes the catalytic core of the ?-secretase multi-protein complex responsible for activating critical signaling cascades during development and for the production of ?-amyloid peptides (A?) implicated in Alzheimer's disease. The only other known GXGD-type diaspartyl intramembrane proteases are the eukaryotic signal peptide peptidases (SPPs). The presence of presenilin-like enzymes outside eukaryots has not been demonstrated. Here we report the existence of presenilin-like GXGD-type diaspartyl intramembrane proteases in archaea.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Identification of an archaeal presenilin-like intramembrane protease.
pubmed:affiliation
Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.