Linked Life Data

20924955

Source:http://linkedlifedata.com/resource/pubmed/id/20924955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-6
pubmed:abstractText
Tert-butyldiphenylsilyl (TBDPS) was testified to be an appropriate orthogonal protecting group for novel 7-hydroxyl-functionalized 8-aza-7-deaza-2'-deoxyadenosine analogues. It was stable in partial and complete hydrogenation reactions used for the different linker preparation. The corresponding phosphoramidites and hydroxyl-functionalized oligodeoxynucleotides were synthesized and identified. The thermal effect of the hydroxyl group with different linkers on DNA duplexes was evaluated. It provided a feasible strategy for the preparation of hydroxyl-functionalized DNAs for the nucleic acid research.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1532-2335
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
734-47
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Hydroxyl-functionalized DNAs with different linkers and their complementary duplex stability.
pubmed:affiliation
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, P. R. China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't