Linked Life Data

20923266

Source:http://linkedlifedata.com/resource/pubmed/id/20923266

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-6
pubmed:abstractText
Evaluation of: Nakayama Y, Plisch EH, Sullivan JM et al. Role of PKR and type I IFNs in viral control during primary and secondary infection. PLoS Pathog. 6(6), e1000966 (2010). During acute viral infections, innate antiviral immunity has been extensively studied for its ability to inhibit and/or control viral replication while priming the adaptive immune system. Recently, these processes have been studied for their role in assisting adaptive immunity to effectively clear or control viral rechallenge. The paper under evaluation introduces the concept that functional innate immune mechanisms such as dsRNA-activated protein kinase (PKR) and type I interferons are critical in controlling viral replication during secondary lymphocyte choriomeningitis virus infection. Elegant adoptive transfer studies revealed that during lymphocyte choriomeningitis virus secondary infections, dependence of viral control relied on expression of these innate factors in virally infected cells and not in adaptive immune T cells. Such findings illustrate that functional adaptive responses are less effective in providing protection against reinfections in the absence of innate mechanisms. This demonstrates the importance of intact innate mechanisms when considering effective vaccine strategies.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Oct
pubmed:issn
1744-8395
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1143-7
pubmed:year
2010
pubmed:articleTitle
Effective control of viral infections by the adaptive immune system requires assistance from innate immunity.
pubmed:affiliation
Center for Gene Therapeutics and Institute for Infectious Disease Research, McMaster University – MDCL 4074, 1200 Main Street West, Hamilton, ON, L8N 3Z5, Canada.
pubmed:publicationType
Journal Article, Comment