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rdf:type |
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lifeskim:mentions |
umls-concept:C0008976,
umls-concept:C0020672,
umls-concept:C0021289,
umls-concept:C0035168,
umls-concept:C0036572,
umls-concept:C0085862,
umls-concept:C0175668,
umls-concept:C0205210,
umls-concept:C0752304,
umls-concept:C0936012,
umls-concept:C1274040,
umls-concept:C1299583,
umls-concept:C1511726,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1882071
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-8
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pubmed:abstractText |
It remains controversial as to whether neonatal seizures have additional direct effects on the developing brain separate from the severity of the underlying encephalopathy. Using data collected from infants diagnosed with hypoxic-ischemic encephalopathy, and who were enrolled in an National Institute of Child Health and Human Development trial of hypothermia, we analyzed associations between neonatal clinical seizures and outcomes at 18 months of age. Of the 208 infants enrolled, 102 received whole body hypothermia and 106 were controls. Clinical seizures were generally noted during the first 4 days of life and rarely afterward. When adjustment was made for study treatment and severity of encephalopathy, seizures were not associated with death, or moderate or severe disability, or lower Bayley Mental Development Index scores at 18 months of life. Among infants diagnosed with hypoxic-ischemic encephalopathy, the mortality and morbidity often attributed to neonatal seizures can be better explained by the underlying severity of encephalopathy.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR16587,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR30,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR39,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR44,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR6022,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR633,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR70,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR7122,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR750,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR80,
http://linkedlifedata.com/resource/pubmed/grant/GCRC M01 RR8084,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD021364-25,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD21364,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD21373,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD21385,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD21397,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD27851,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD27853,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD27856,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD27871,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD27880,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD27904,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD34216,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD36790,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD40461,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD40492,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD40498,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD40521,
http://linkedlifedata.com/resource/pubmed/grant/U10 HD40689
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1708-8283
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pubmed:author |
pubmed-author:DonovanEdward FEF,
pubmed-author:DuChinC,
pubmed-author:EhrenkranzRichard ARA,
pubmed-author:FanaroffAvroy AAA,
pubmed-author:GoldbergRonald NRN,
pubmed-author:GuilletRonnieR,
pubmed-author:HigginsRosemary DRD,
pubmed-author:KwonJennifer MJM,
pubmed-author:LaptookAbbot RAR,
pubmed-author:McDonaldScott ASA,
pubmed-author:O'SheaT MichaelTM,
pubmed-author:PooleW KennethWK,
pubmed-author:ShankaranSeethaS,
pubmed-author:TysonJon EJE,
pubmed-author:WalshMichele CMC
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
322-8
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pubmed:meshHeading |
pubmed-meshheading:20921569-Developmental Disabilities,
pubmed-meshheading:20921569-Disability Evaluation,
pubmed-meshheading:20921569-Electroencephalography,
pubmed-meshheading:20921569-Female,
pubmed-meshheading:20921569-Humans,
pubmed-meshheading:20921569-Hypothermia, Induced,
pubmed-meshheading:20921569-Hypoxia-Ischemia, Brain,
pubmed-meshheading:20921569-Infant,
pubmed-meshheading:20921569-Male,
pubmed-meshheading:20921569-National Institute of Child Health and Human Development...,
pubmed-meshheading:20921569-Seizures,
pubmed-meshheading:20921569-Time Factors,
pubmed-meshheading:20921569-Treatment Outcome,
pubmed-meshheading:20921569-United States
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pubmed:year |
2011
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pubmed:articleTitle |
Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial.
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pubmed:affiliation |
Departments of Neurology and Pediatrics, University of Rochester, Rochester, New York 14642, USA. jennifer_kwon@urmc.rochester.edu
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, N.I.H., Extramural
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