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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2010-10-19
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pubmed:abstractText |
We previously demonstrated that conditional overexpression of neuronal nitric oxide synthase (nNOS) inhibited L-type Ca2+ channels and decreased myocardial contractility. However, nNOS has multiple targets within the cardiac myocyte. We now hypothesize that nNOS overexpression is cardioprotective after ischemia/reperfusion because of inhibition of mitochondrial function and a reduction in reactive oxygen species generation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BlömerNadjaN,
pubmed-author:BullaJanJ,
pubmed-author:BurkardNatalieN,
pubmed-author:CzolbeMartinM,
pubmed-author:FraccarolloDanielaD,
pubmed-author:FrantzStefanS,
pubmed-author:HanHongH,
pubmed-author:HofmannUlrichU,
pubmed-author:LinkMartinM,
pubmed-author:NiM XMX,
pubmed-author:NordbeckPeterP,
pubmed-author:PantherFranziskaF,
pubmed-author:RitterOliverO,
pubmed-author:SchuhKaiK,
pubmed-author:WidderJulian DJD,
pubmed-author:WilliamsTatjanaT
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1588-603
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pubmed:meshHeading |
pubmed-meshheading:20921441-Animals,
pubmed-meshheading:20921441-Electron Transport Complex IV,
pubmed-meshheading:20921441-Female,
pubmed-meshheading:20921441-Male,
pubmed-meshheading:20921441-Mice,
pubmed-meshheading:20921441-Mice, Transgenic,
pubmed-meshheading:20921441-Mitochondria, Heart,
pubmed-meshheading:20921441-Models, Animal,
pubmed-meshheading:20921441-Myocardial Infarction,
pubmed-meshheading:20921441-Myocardial Reperfusion Injury,
pubmed-meshheading:20921441-NADPH Oxidase,
pubmed-meshheading:20921441-Nitric Oxide Synthase Type I,
pubmed-meshheading:20921441-Oxygen Consumption,
pubmed-meshheading:20921441-Reactive Oxygen Species,
pubmed-meshheading:20921441-Ventricular Dysfunction, Left
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pubmed:year |
2010
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pubmed:articleTitle |
Conditional overexpression of neuronal nitric oxide synthase is cardioprotective in ischemia/reperfusion.
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pubmed:affiliation |
Department of Medicine I, University of Wuerzburg, Oberduerrbacherstrasse 6, Wuerzburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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