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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-3
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pubmed:abstractText |
TRPM2 is a Ca²(+)-permeable nonselective cation channel activated by adenosine dinucleotides. We previously demonstrated that TRPM2 is activated by coapplication of heat and intracellular cyclic adenosine 5'-diphosphoribose, which has been suggested to be involved in intracellular Ca²(+) increase in immunocytes and pancreatic ?-cells. To clarify the involvement of TRPM2 in insulin secretion, we analyzed TRPM2 knockout (TRPM2-KO) mice.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1939-327X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-26
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20921208-Animals,
pubmed-meshheading:20921208-Blood Glucose,
pubmed-meshheading:20921208-Calcium,
pubmed-meshheading:20921208-Glucose Tolerance Test,
pubmed-meshheading:20921208-Hot Temperature,
pubmed-meshheading:20921208-Insulin,
pubmed-meshheading:20921208-Islets of Langerhans,
pubmed-meshheading:20921208-Male,
pubmed-meshheading:20921208-Mice,
pubmed-meshheading:20921208-Mice, Knockout,
pubmed-meshheading:20921208-TRPM Cation Channels
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pubmed:year |
2011
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pubmed:articleTitle |
Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.
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pubmed:affiliation |
National Institutes of Natural Sciences, Okazaki, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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