Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Suppl
|
| pubmed:dateCreated |
1991-6-12
|
| pubmed:abstractText |
We have evaluated Langerhans cell (LC) distribution in 19 lung carcinomas and 1 carcinoid tumor, furthermore investigating HLA class II molecules expression by the neoplastic cells; this was done using, in immunohistochemical tests, a polyclonal antiserum anti S-100 protein for the identification of LCs and a mouse Monoclonal Antibody (MoAb) for the detection of HLA class II -DR molecules. Our results indicate that LCs are poorly represented in lung carcinomas and likewise HLA class II molecules are scarcely expressed by the neoplastic cells; this might be important in understanding the ominous prognosis of lung carcinomas since both parameters investigated play a central role in the immune response against human neoplasia, LCs as antigen presenting cells and HLA class II molecule as restriction elements during antigen stimulation of CD4+ T lymphocytes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0392-0208
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
185-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading | |
| pubmed:articleTitle |
Langerhans cell and HLA class II molecules distribution in lung carcinoma.
|
| pubmed:affiliation |
Dept. of Pathology, Università Cattolica del Sacro Cuore (AC&GB), Italy.
|
| pubmed:publicationType |
Journal Article
|