Linked Life Data

20920550

Source:http://linkedlifedata.com/resource/pubmed/id/20920550

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-11-24
pubmed:abstractText
The fine-tuning of topographically organized projections in sensory systems is strongly influenced by electrical activity and use-dependent modifications in synaptic strength. Since calcineurin (CaN), a Ca(2+)-calmodulin dependent serine/threonine phosphatase has been associated with activity-dependent modifications in synaptic efficacy we studied the effects of systemic and local administration of CaN inhibitors during the critical period of development of the uncrossed retinocollicular projection in pigmented rats. We found that the expression of the catalytic subunit of calcineurin (CaNA) occurs throughout early development in the visual layers of the superior colliculus and peaks at PND14 when eye opening is complete. The functional blockade of CaN activity by means of a systemic treatment with cyclosporine A (CsA) during the second postnatal week, induces sprouting of uncrossed retinal axons outside their main terminal zones. Additionally, the local treatment with intracranial implants of Elvax loaded with either CsA or a cell-permeable CaN inhibitory peptide (CIP) resulted in a similar expansion of retinocollicular terminal fields. Taken together, these results suggest CaN as a key element for the development of fine tuning of retinocollicular topography.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1872-7972
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
487
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-52
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Evidence for a role of calcineurin in the development of retinocollicular fine topography.
pubmed:affiliation
Biology Institute, Federal Fluminense University, Niteroi, RJ, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't