|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021756,
umls-concept:C0033268,
umls-concept:C0034819,
umls-concept:C0039194,
umls-concept:C0072442,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0205307,
umls-concept:C0229664,
umls-concept:C1518062,
umls-concept:C1627358,
umls-concept:C2349975,
umls-concept:C2911684
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1991-6-7
|
|
pubmed:abstractText |
The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0892-3973
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
595-617
|
|
pubmed:dateRevised |
2009-5-14
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|
pubmed:meshHeading |
|
|
pubmed:year |
1990
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|
pubmed:articleTitle |
Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes.
|
|
pubmed:affiliation |
Department of Immunology, Hellenic Anticancer Institute, Athens, Greece.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
