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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1978-9-29
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pubmed:abstractText |
Cell lines were established from 2 primary hepatocellular carcinomas (HC's) and 3 sarcomas produced in Syrian golden hamsters inoculated as newborns with chicken embryo lethal orphan (CELO) virus. Cell lines from 2 sarcomas (COT, CMT) and 1 HC (CEHEP) produced CELO virus-specific T-antigen. The antigen was not detected in cells of the third sarcoma line (RCT) until they had undergone more than 34 passages in vitro. Although 5-10% of cells in the second HC line (CILT/2) contained T-antigen during early passages, it was not demonstrable after the fifth subculture. Nevertheless, cells of both HC lines possessed CELO virus tumor-specific transplantation antigen. All 5 cell lines also contained hamster type R particles, and both HC lines had type C and intracytoplasmic type A particles. The percentage of carcinoma cells producing type R particles increased during cultivation in vitro, whereas the number of cells with type A particles decreased. Treatment with dibutyryl cyclic AMP and theophylline enhanced the number of cells producing type C particles in 1 HC line and type R particles in 2 sarcoma lines.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8874
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:209200-Adenoviridae,
pubmed-meshheading:209200-Adenoviridae Infections,
pubmed-meshheading:209200-Adolescent,
pubmed-meshheading:209200-Animals,
pubmed-meshheading:209200-Antigens, Viral,
pubmed-meshheading:209200-Aviadenovirus,
pubmed-meshheading:209200-Bucladesine,
pubmed-meshheading:209200-Carcinoma, Hepatocellular,
pubmed-meshheading:209200-Cell Line,
pubmed-meshheading:209200-Cricetinae,
pubmed-meshheading:209200-Histocompatibility Antigens,
pubmed-meshheading:209200-Humans,
pubmed-meshheading:209200-Inclusion Bodies, Viral,
pubmed-meshheading:209200-Liver Neoplasms,
pubmed-meshheading:209200-Mesocricetus,
pubmed-meshheading:209200-Neoplasms, Experimental,
pubmed-meshheading:209200-Sarcoma, Experimental,
pubmed-meshheading:209200-Virus Replication
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pubmed:year |
1978
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pubmed:articleTitle |
Virus-specific markers and virus-like particles in cell lines of tumors produced by CELO virus in Syrian golden hamsters.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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