Linked Life Data

2091869

Source:http://linkedlifedata.com/resource/pubmed/id/2091869

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-6-13
pubmed:abstractText
Degradation of indocyanine green solution by exposure to light was studied by high-pressure liquid chromatography. Indocyanine green in an aqueous medium exposed to light changed rapidly into an unknown product. The plasma clearance rate and the biliary excretion rate of the unknown product were much slower than those of indocyanine green. Spectrophotometric scan revealed that the unknown product had almost the same absorption spectrum as indocyanine green. Therefore, if degraded indocyanine green solution were to be used in a liver function test, the clearance of indocyanine green assayed by spectrophotometry would apparently be much lower than that of undegraded indocyanine green. According to fast atom bombardment mass spectrometry, the molecular weight of the unknown product was 723, whereas that of indocyanine green was 775. The analysis of rat bile after injection of indocyanine green by high-pressure liquid chromatography revealed that about 1% of the administered indocyanine green was metabolized in the rat liver.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0040-8921
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-69
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Degradation and metabolism of indocyanine green: high-pressure liquid chromatographic analysis.
pubmed:affiliation
Third Department of Internal Medicine, Tokyo Medical and Dental University.
pubmed:publicationType
Journal Article, In Vitro