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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-6-3
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pubmed:abstractText |
The World Health Organization (WHO) extended field test was employed to assess the in vivo sensitivity of Plasmodium falciparum to sulfadoxine-pyrimethamine combination in 44 children in Zaria urban area. 36 children (82%) were fully sensitive to the drug and 8 (18%) were resistant at the RI level. 8 parasite isolates were obtained from the children and successfully cultured in vitro using the WHO microtest (mark II) system. The 8 isolates underwent schizogony at concentrations of 10,000 pmol sulfadoxine/125 pmol pyrimethamine per well, indicating in vitro resistance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
0035-9203
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
505-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2091339-Animals,
pubmed-meshheading:2091339-Antimalarials,
pubmed-meshheading:2091339-Child,
pubmed-meshheading:2091339-Child, Preschool,
pubmed-meshheading:2091339-Drug Combinations,
pubmed-meshheading:2091339-Drug Resistance,
pubmed-meshheading:2091339-Humans,
pubmed-meshheading:2091339-Infant,
pubmed-meshheading:2091339-Malaria,
pubmed-meshheading:2091339-Nigeria,
pubmed-meshheading:2091339-Plasmodium falciparum,
pubmed-meshheading:2091339-Pyrimethamine,
pubmed-meshheading:2091339-Sulfadoxine
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pubmed:articleTitle |
Resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine combination in semi-immune children in Zaria, northern Nigeria.
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pubmed:affiliation |
Department of Pharmacology, Ahmadu Bello University, Zaria, Nigeria.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
In Vitro
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