Linked Life Data

2089914

Source:http://linkedlifedata.com/resource/pubmed/id/2089914

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-5-24
pubmed:abstractText
We investigated the effects of murine recombinant interleukin-1 (rIL-1, Du Pont) in vivo in the normal rat brain and here report both local and systemic effects of centrally administered rIL-1. Normal rats were given single or multiple atraumatic doses of either rIL-1 or and equal volume (5 microliters) of vehicle for control comparison. All dosages of intraparenchymal rIL-1 produced a uniform a hyperthermic response and concomitant lethargy. There was a related anorexia beyond fever duration. Histologic examination of intraparenchymal injection tracts revealed fibrillary whorls of oedema and a cellular infiltrate surrounding the rIL-1 tract, while similar changes were less prominent in control injection tracts. Repeated high doses of rIL-1 produced significantly higher concentrations of brain water as measured by the gravimetric technique. We conclude that rIL-1 is not only a potent chemoattractant, but is also an edigematic agent when administered in high doses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1419
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
268-70
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Effect of murine recombinant interleukin-1 on brain oedema in the rat.
pubmed:affiliation
Division of Neurosurgery, Medical College of Virginia, Richmond.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't