Linked Life Data

2089168

Source:http://linkedlifedata.com/resource/pubmed/id/2089168

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-5-24
pubmed:abstractText
The toxicity of bis (tri-n-butyltin) oxide (TBTO) was studied in THA rats. Doses of 0 (control), 10 or 15 mg/kg/day of TBTO were administered to adult rats for 12 consecutive days, and 0, 5 or 10 mg/kg/day was given to pregnant rats from day 6 to day 20 of gestation by gastric intubation. In the adult rat exposure experiment, the 15 mg/kg group showed slightly decreased body weight and spontaneous motor activity, and a low avoidance rate in the Sidman avoidance test in the early stage of administration. In the pregnant-rat exposure experiment, no effect of TBTO was seen in either the 5 mg/kg or 10 mg/kg groups in dams while all pups in the 10 mg/kg group died by postnatal day 3. Little effect of TBTO on body weight, pinna detachment, incisor eruption, eye opening, surface righting, cliff avoidance, pivoting, negative geotaxis and auditory startle was found in the 5 mg/kg pups. In the Sidman avoidance test, the avoidance rate of the 5 mg/kg pups was lower than that of control pups in the early stage of the session. In a water E-maze test, the swimming time to the goal and the number of errors were increased in the 5 mg/kg pups. In a reversal water E-maze test, increases of the swimming time to the goal and the number of errors made by the 5 mg/kg pups were marked. These results suggest that TBTO administration disrupts the learning acquisition of rats, and that the toxicity of TBTO is greater in prenatally exposed pups than in adult rats.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-5082
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
926-34
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Toxicity of bis (tri-n-butyltin) oxide on learning and development in the rat].
pubmed:affiliation
Department of Environmental Medicine and Occupational Health, Tokai University School of Medicine, Kanagawa.
pubmed:publicationType
Journal Article, English Abstract