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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-2-9
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pubmed:abstractText |
In our screening program for bioactive natural products from our library of tropical plants, the extract prepared from the roots of Stemona javanica inhibited NO production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide (LPS). Bioassay-guided fractionation of the extract from S. javanica led to the isolation of two active compounds, stemofoline (1) and stemanthrene C (2). The inhibition mechanism of 1 was proposed to suppress iNOS expression in J774.1 cells stimulated by LPS, whereas that of 2 was due to potent radical scavenging activity resulting in NO inhibitory activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1439-0221
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pubmed:author |
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pubmed:copyrightInfo |
© Georg Thieme Verlag KG Stuttgart · New York.
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pubmed:issnType |
Electronic
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
256-8
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pubmed:meshHeading |
pubmed-meshheading:20890808-Animals,
pubmed-meshheading:20890808-Antioxidants,
pubmed-meshheading:20890808-Cell Line,
pubmed-meshheading:20890808-Heterocyclic Compounds with 4 or More Rings,
pubmed-meshheading:20890808-Lipopolysaccharides,
pubmed-meshheading:20890808-Macrophages,
pubmed-meshheading:20890808-Mice,
pubmed-meshheading:20890808-Nitric Oxide,
pubmed-meshheading:20890808-Nitric Oxide Synthase Type II,
pubmed-meshheading:20890808-Phenanthrenes,
pubmed-meshheading:20890808-Plant Extracts,
pubmed-meshheading:20890808-Plant Roots,
pubmed-meshheading:20890808-Stemonaceae
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pubmed:year |
2011
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pubmed:articleTitle |
Inhibitors of nitric oxide production from Stemona javanica.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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