Linked Life Data

20890662

Source:http://linkedlifedata.com/resource/pubmed/id/20890662

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pubmed-article:20890662pubmed:abstractTextEnterotoxigenic Eschoerchia coli (ETEC) F4 is a major cause of diarrhea in neonatal and young pigs. The locus encoding intestinal receptor for ETEC F4ab/ac has been mapped to pig chromosome (SSC) 13q41. We previously assigned mucin 20 (MUC20) to SSC13q41 and considered it a candidate for the ETEC F4ab/ac receptor. In this study, the full-length mRNA sequence of the porcine MUC20 gene was determined, revealing two MUC20 alternative transcripts differing in an 18-bp deletion in the open reading frame (ORF). The longer isoform is 1,927-bp long and contains a 1,572-bp ORF encoding a protein of 523 amino acids. RT-PCR analysis showed that MUC20 mRNA was expressed most highly in the kidney, prostate, epididymis and bladder. Seven single nucleotide polymorphisms in MUC20 were identified in founder animals of a White Duroc × Erhualian cross, and the entire cross population (n = 842) was genotyped for two MUC20 polymorphisms: g.191C>T in intron 5 and c.1600C>T in exon 6. The transmission disequilibrium test (TDT) results revealed that both polymorphisms were significantly associated with in vitro ETEC F4ab/ac adhesion phenotypes in the intercross population, and the most significant association was found between g.191C>T and F4ac adhesion phenotype (P = 1.02 × 10(-9)).lld:pubmed
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pubmed-article:20890662pubmed:authorpubmed-author:ZhangBoBlld:pubmed
pubmed-article:20890662pubmed:authorpubmed-author:HuangXiangXlld:pubmed
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pubmed-article:20890662pubmed:authorpubmed-author:ZhangZhiyanZlld:pubmed
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pubmed-article:20890662pubmed:articleTitleThe porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac.lld:pubmed
pubmed-article:20890662pubmed:affiliationKey Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, 330045 Nanchang, China.lld:pubmed
pubmed-article:20890662pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20890662pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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