Linked Life Data

20890230

Source:http://linkedlifedata.com/resource/pubmed/id/20890230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2010-11-3
pubmed:abstractText
Menthol is known as an agonist for cold-sensitive transient receptor potential channels (TRPM8) and also as a direct modulator of GABA channels. We examined the effects of menthol on respiratory rhythm generation in the brainstem-spinal cord preparations isolated from newborn rats. Menthol decreased respiratory rhythm dose-dependently (0.1-1 mM). Effects of menthol were reversed by the GABAA antagonist, bicuculline. Menthol caused pronounced reduction in the driving potential of pre-inspiratory but not inspiratory neurons. Expression of the TRPM8 channel protein was not detected in the respiratory related region of the rostral ventrolateral medulla by immunohistochemistry. The results suggest that the potent inhibitory action of menthol on burst generation of pre-inspiratory neurons is because of direct activation of tonic GABA channels by menthol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1473-558X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
8
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1095-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Menthol inhibits the respiratory rhythm in brainstem preparations of the newborn rats.
pubmed:affiliation
Department of Physiology, Showa University School of Medicine, Hatanodai, Shinagawa-ku, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't