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rdf:type |
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lifeskim:mentions |
umls-concept:C0003209,
umls-concept:C0017243,
umls-concept:C0033684,
umls-concept:C0204727,
umls-concept:C0205314,
umls-concept:C0205409,
umls-concept:C0679622,
umls-concept:C0718566,
umls-concept:C0871161,
umls-concept:C1515999,
umls-concept:C1880022,
umls-concept:C2825121
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-21
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pubmed:abstractText |
The Aloe protein of 14 kDa from the Aloe vera leaf gel was isolated by an ion exchange chromatography using DEAE-cellulose and CM-cellulose column. The purified Aloe protein exhibited a potent anti-fungal activity against Candida paraprilosis, Candida krusei and Candida albicans. In addition, the purified Aloe protein also showed an anti-inflammatory property against pure lipoxygenase and cyclooxygenase-2 with 84% and 73% inhibition, respectively, and was verified by binding with these proteins by real time method by the phenomenon of surface plasmon resonance. This Aloe protein is a novel protein possessing antifungal and anti-inflammatory properties and thus sets a platform to be used as a medicinal plant product.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1879-0003
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pubmed:author |
pubmed-author:AshrafMd SaquibMS,
pubmed-author:DalalKrishnaK,
pubmed-author:DasSwagataS,
pubmed-author:DeySharmisthaS,
pubmed-author:GillKamaldeepK,
pubmed-author:MishraBiswajitB,
pubmed-author:SharmaSujataS,
pubmed-author:SinghAbhay KumarAK,
pubmed-author:SinghTej PalTP,
pubmed-author:SinhaMouM,
pubmed-author:XessImmaculataI
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
48
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
38-43
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pubmed:meshHeading |
pubmed-meshheading:20888359-Aloe,
pubmed-meshheading:20888359-Anti-Inflammatory Agents,
pubmed-meshheading:20888359-Antifungal Agents,
pubmed-meshheading:20888359-Candida,
pubmed-meshheading:20888359-Cyclooxygenase 2,
pubmed-meshheading:20888359-DEAE-Cellulose,
pubmed-meshheading:20888359-Enzyme Assays,
pubmed-meshheading:20888359-Gels,
pubmed-meshheading:20888359-Hemagglutination,
pubmed-meshheading:20888359-Humans,
pubmed-meshheading:20888359-Lipoxygenase,
pubmed-meshheading:20888359-Microbial Sensitivity Tests,
pubmed-meshheading:20888359-Peptide Hydrolases,
pubmed-meshheading:20888359-Plant Leaves,
pubmed-meshheading:20888359-Plant Proteins,
pubmed-meshheading:20888359-Protease Inhibitors,
pubmed-meshheading:20888359-Sequence Analysis, Protein,
pubmed-meshheading:20888359-Sequence Homology, Amino Acid,
pubmed-meshheading:20888359-Spectrophotometry
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pubmed:year |
2011
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pubmed:articleTitle |
Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel.
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pubmed:affiliation |
Department of Biophysics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
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pubmed:publicationType |
Journal Article
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